Dexamethasone Ibuprofen Prodrug Synthesis and Preliminary Kinetic Study
نویسندگان
چکیده
منابع مشابه
Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug
BACKGROUND: Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated to a tumor-specific antibody. The antibody selectively localizes the enzyme to the tumor cell surface. Subsequent administration of a prodrug substrate of the enzyme leads to the enzyme-catalyzed release of the...
متن کاملNovel ibuprofen medoxomil prodrug: Design, synthesis and in vitro stability evaluation
Synthesis of medoxomil prodrug of ibuprofen (IM) was described. Its stabilities at different pH environments encountered in the gastrointestinal tract and in rat plasma in vitro were tested. Results demonstrated that esterase play an important role in the activation of IM. It can pass through the stomach without degradation, and with very slow degradation in intestinal tract, which indicated th...
متن کاملKinetic Study of Decomposition of Ibuprofen under Isothermal Conditions
BOGDAN TITA,1,2* ADRIANA FULIAS,1 MIRCEA STEFÃNESCU,2 ELEONORA MARIAN,3 DUMITRU TITA1 1 University of Medicine and Pharmacy “Victor Babeo”, Faculty of Pharmacy, 2 Eftimie Murgu Square, Timisoara, 300041, Romania 2 Politehnica University of Timiooara, Industrial Chemistry and Environmental Engineering Faculty, 2 Victoriei Square , Timiooara, 300006, Romania 3 Oradea University, Faculty of Medici...
متن کاملSensitive liquid chromatographic assay for the simultaneous determination of ibuprofen and its prodrug, ibuprofen eugenol ester, in rat plasma.
A rapid, sensitive, and specific reverse-phase high-performance liquid chromatography (HPLC) method was developed to quantitate ibuprofen (IBU) and its prodrug, ibuprofen eugenol ester (IEE), simultaneously in rat plasma. IBU, IEE, and the internal standard glycryrrhetic acid (GA) were detected by UV absorption at 230 nm. Extraction recoveries for all compounds ranged between 82.6% and 96.2%. R...
متن کاملMacromolecular Prodrug of Dexamethasone Preserves Bone in Inflammatory Arthritis: A Micro- CT Study
Aims Rheumatoid arthritis (RA) is an autoimmune disease characterized by a chronic inflammation of synovium, leading to joint destruction. Local and systemic inflammation favors periarticular and generalized osteopenia/osteoporosis, producing deformity, laxity, functional disability and increased risk for fractures, which is a hallmark of RA. It is well acknowledged that bone loss is a major an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Products Chemistry & Research
سال: 2014
ISSN: 2329-6836
DOI: 10.4172/2329-6836.1000106